49ers vs. Cowboys odds, prediction for NFL wild-card playoff game

When the 49ers take on the Cowboys in Dallas in the No. 6 vs. No. 3 NFC playoff game (4:40 p.m. ET, CBS, Nickelodeon, Amazon Prime Video), it will have the look and feel of a classic showdown between the two teams. San Francisco was the last NFC team to qualify with its Week 18 win, while Dallas moved up one spot because of that result.

The 49ers started slowly, but with improved offensive health and efficiency, plus a defensive front that rises to overcome secondary problems, is back in the playoffs at 10-7 after a one-year absence following Super Bowl 54 with Kyle Shanahan. The Cowboys, who lost Dak Prescott to a major ankle injury early in 2020, rebounded to 12-5 in the second season under Mike McCarthy.

Who will win this exciting matchup between two teams with a lot of potential?

Here’s everything there is to know about betting on the 49ers vs. Cowboys in the 2022 NFL playoffs, including updated odds, trends and our expert’s prediction for the wild card game.

The Cowboys have been consistent favorites on field goals from the opening line. The 49ers have posted fairly favorable numbers for several consecutive weeks since their midseason turnaround. The point total has continued to climb.

49ers vs Cowboys Prediction.

The 49ers will be a tough opponent right off the bat, as Garoppolo will continue to grind through injuries and find favorable matchups to move the ball with his weapons. They will stay in the game by running often and controlling the clock in an attempt to keep Prescott off the field and protect the defense. But in the end, Prescott makes a big difference with his arm and legs, while the Cowboys defense saves the day at the end with one of their signature big plays.

Cowboys 31, 49ers 24

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